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04/23/08 7:33 PM ET

Griffey hits home run No. 597

CINCINNATI -- Ken Griffey Jr. edged closer to career home run No. 600 in the first inning of Wednesday night's series opener against the Astros at Great American Ball Park.

Griffey launched a 2-0 pitch from Houston right-hander Chris Sampson into the right-field stands for career homer No. 597.

Griffey's solo homer, which traveled an estimated 424 feet, put the Reds ahead 1-0.

It was his 199th home run in a Reds uniform, moving him into sole possession of eighth place on the franchise's all-time home run list ahead of former shortstop Barry Larkin.

Sampson is the 381st different pitcher off which Griffey has homered.

Jeff Wallner is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.