Chicago will look to rebound after being swept by the Royals over the weekend. The White Sox were held hitless through 6 2/3 innings by Jeremy Guthrie in Sunday's 5-2 loss.
The Yankees, meanwhile, haven't dropped a series since losing two of three to the Orioles in late July. They kept that run alive on Sunday night with a 4-1 win over the Red Sox.
Gavin Floyd will take the mound for the White Sox in the opener. The right-hander has thrown quality starts in five of his past six outings to lower his ERA to 4.43.
On Wednesday, Floyd earned his first win since July 23, when he limited the Blue Jays to four runs -- three earned -- over six innings. He opened the game with four scoreless innings but gave up a run in the fifth and a three-run home run to Kelly Johnson in the sixth.
"Gavin came out throwing strikes," manager Robin Ventura said after the game. "He was great early on. He made the one mistake to Johnson, but he pitched great. He looked good."
A rejuvenated Freddy Garcia gets the nod for New York against one of his former clubs. Since rejoining the rotation after Andy Pettitte went down with a fractured left ankle, Garcia is 5-3 with a 3.69 ERA in nine starts. Garcia showed no signs of slowing down in his last outing, allowing two runs over 6 2/3 innings against the Rangers on Wednesday to pick up his third consecutive win.
"Ever since he came back from the bullpen, he's been tremendous," Yankees catcher Russell Martin said after that game. "I think part of it is he's gotten his velocity back. When his velocity is up, his pitches are a little sharper and a little crisper."
Yankees: Sabathia feels good after bullpen session
Yankees ace CC Sabathia threw about 20 pitches in a bullpen session at Yankee Stadium on Saturday and reported no issues with his left elbow. Sabathia said he will be ready to pitch on Friday -- the first day he is eligible to be activated from the 15-day disabled list -- against the Indians at Progressive Field.
"Pending any kind of setbacks or swelling or anything, I should be ready to go," Sabathia said on Saturday. "I haven't had any of that the past couple of days, so I should be good.
"It's been really good the past couple of days. I'm just doing a lot of stretching, a lot of treatment -- a lot during the game and at home. The range of motion has gotten a lot better."
Third baseman Eric Chavez is batting .465 (20-for-43) with 10 runs, two doubles, five homers and 10 RBIs over his last 14 games.
White Sox: Youkilis gets breather after milestone
Kevin Youkilis must hold himself to pretty high standards.
On Sunday, the day after he recorded the 1,000th hit of his career -- a sharp eighth-inning liner to left off Kansas City's Tim Collins -- Youkilis shared what the milestone meant to him.
"It's pretty cool for the family and friends," Youkilis said. "But for me, I would tell you I should have gotten 1,000 hits a long time ago by playing better. It's nice to have a number, but I hope it goes way higher than that."
Youkilis got the day off Sunday to rest the right knee that has been bothering him lately.
Chicago is hitting .255 (36-for-141) with six homers, owns a 4.76 ERA (18 earned runs in 34 innings) and has outscored the Yankees, 20-18, in its games against New York this year.
The Yankees are 51-6 (.895) this season when holding their opponent to three or fewer runs, the second-best winning percentage in the Majors in such games, behind the Mets (42-4, .913).
The White Sox have played 75 games decided by three runs or fewer this season, and they are 18-15 in one-run games, 11-17 in two-run games and 8-6 in three-run contests. Chicago has won 11 of its last 15 one-run games.