The former Padres ace turned Reds right-hander has dominated the West while the Central has knocked him around in 2012.
Against NL West foes this season, Latos boasts a 1.78 ERA as opposed to a 7.11 mark when facing an NL Central opponent.
The 24-year-old will get a chance to continue his success against his former division Wednesday when the Reds host the D-backs in the third game of the four-game series.
The last time Latos took the mound against a NL West team was July 6, when he tossed seven shutout innings in San Diego versus his former club, but received a no-decision as the Reds fell, 2-1.
"It's just another game," Latos said afterwards. "Today was a grind offensively and defensively and pitching. Things didn't go our way today."
Countering Latos for the D-backs will be Ian Kennedy. The 20-game winner from a year ago has struggled to find the same consistency this season that made him a Cy Young candidate in 2011.
In his last two outings, Kennedy has surrendered 10 earned runs over 12 innings.
"It's really, really frustrating," he said. "That's all I can tell you. I feel good one outing and then I don't know what happens the next outing. It's two completely different people. It's frustrating for me."
In two April starts last season against the Reds, Kennedy pitched his way to two wins by allowing just two runs in 13 1/3 innings.
Reds: Redmond gets called up to help Reds 'pen
With Joey Votto going on the 15-day disabled list Tuesday, the Reds opted to add a 13th pitcher by recalling right-hander Todd Redmond from Triple-A Louisville.
"We need innings," Reds manager Dusty Baker said. "I was in that bullpen deep and early [Monday]. A couple of guys have thrown two out of three days or three out of four days."
Redmond was traded from the Braves to the Reds on Saturday for shortstop Paul Janish.
"They just want me for a long relief role type of thing. That's all I know," Redmond said. "As long as I'm here, I'm fine. I'm just happy to be here."
Redmond, who has never pitched in the big leagues, was 6-6 with a 3.58 ERA in 18 starts for Gwinnett this season. His stay on the 25-man roster for Cincinnati is tenuous because the Reds still need an extra hitter even though Baker would not speculate on plans past Tuesday.
"We'll see what we can do tomorrow," Baker said. "We have things in the works. If I say 'yeah,' and the bat doesn't come, then you look bad."
D-backs: Kubel close to returning
Jason Kubel could be ready to start Wednesday after leaving Friday's game against the Cubs early with tightness in his hamstring and not playing since, aside from a pinch-hit appearance Saturday in Chicago.
D-backs manager Kirk Gibson said the club feels the left fielder is nearly back to full strength.
"I talked to [head athletic trainer] Ken [Crenshaw] after the game and we just felt another day," Gibson said. "I think he's getting better. I think we're seeing improvement. I'd love him in the lineup."
Gibson said Kubel plans on running "pretty good" before Tuesday's game in Cincinnati before assessing his health again Wednesday.
"We'll see how he runs," Gibson said. "We went out there yesterday and it was kind of limited. I don't really want him to go out there if he can't run to play the outfield."
Kubel is batting .292 this season and leads the team with 15 home runs and 60 RBIs.
The Reds recorded their 400th win in franchise history at Great American Ball Park on Tuesday against the D-backs. In contrast the club has 373 losses at its home.
The D-backs have scored more than six or less than two runs in 68 percent of their games this season. When they score six or more, the club is 21-6, but when the D-backs score less than two, they are 1-32.