Sidelined with a left groin strain, Sabathia will make his first start since June 24 against the Mets.
"I feel good. My arm feels good," Sabathia said. "I haven't felt my leg [soreness] since the first week of the injury, so I'll be ready to go [Tuesday].
"I've thrown a lot in between. I threw on Sunday, so I feel like I've had enough work off the mound, played enough catch, threw off flat ground, that I should be able to go out and be able to throw strikes."
Sabathia will be up against a Toronto club that's hovered around the .500 mark all season and is in the middle of a crucial six-game road trip against New York and then Boston.
One player Sabathia won't be facing is feared Toronto slugger Jose Bautista, who left Monday's series opener in the eighth inning after injuring his left wrist on a swing.
Bautista was immediately sent for X-rays, which came back negative, but he was placed on the 15-day disabled list Tuesday because of inflammation in the wrist.
"Unfortunately on the swing on the 2-0 fastball, he felt a sensation in that left wrist that obviously took him out of the ballgame," Blue Jays manager John Farrell said.
The Dominican Republic native entered play on Monday just one behind Adam Dunn for most home runs in the Major Leagues with 27. Bautista is hitting .244 with 65 RBIs and an .897 OPS.
Blue Jays: Cecil draws CC in battle of lefties
Brett Cecil will try and help Toronto to its first win on the road trip after a 6-3 loss on Monday.
Cecil was roughed up in his last start against the White Sox, lasting just 4 1/3 innings and surrendering seven runs on six hits for the no-decision.
Brandon Morrow completed another step in his rehab by tossing a 40-pitch bullpen session on Sunday. He's been on the disabled list with a strained left oblique muscle since June 12 and is expected to be out until at least mid-to-late August.
Yankees: Gardner suffers third setback in rehab
Outfielder Brett Gardner suffered a third setback in his attempt to return from a strained right elbow. He took four at-bats on Sunday in a simulated game in Tampa, Fla., but felt soreness on Monday and did not continue his scheduled rehab.
Robinson Cano's third-inning RBI double extended the second baseman's hitting streak to a career-high 19 games. Cano added a single in the eight, helping prolong an inning in which Raul Ibanez's grand slam became the difference in the game.
Yankees reliever Joba Chamberlain will pitch another rehab inning on Tuesday, but manager Joe Girardi was unsure whether it would be with the Gulf Coast League Yankees or Class A Advanced Tampa. The right-hander threw two scoreless innings Saturday with the GCL Yankees as he works to return from Tommy John surgery last June and an open dislocation of his right ankle in March.