Though De Vries' Major League debut came last week against the White Sox, Tuesday's situation will likely stir even more nerves. The 27-year-old said he's ready for it.
"I know they'll be up again because it's the first time pitching at home in front of the hometown crowd," said De Vries, the 14th Golden Gopher to play for the Twins. "But I'm hoping for a steady decline with those and keep them in control as much as possible."
Minnesota ultimately fell at Chicago in De Vries' debut, 11-8, on May 25. But the right-hander's start was encouraging. While he allowed six runs on six hits in five innings, only three of the runs were earned and each came on solo home runs courtesy of veterans A.J. Pierzynski, Paul Konerko and Alex Rios.
Strong winds at U.S. Cellular Field didn't help De Vries, either.
"The ball was still coming out of his hand real good. We like what we saw," Twins manager Ron Gardenhire said. "This is a tough ballpark. You get the ball up here ... it goes."
De Vries' preference for pounding the strike zone may leave him vulnerable to homers, but it's also his biggest asset. De Vries limited opponents to only seven walks in 46 2/3 innings at Triple-A Rochester earlier this year. He issued only one walk against Chicago in his debut.
"That's my game," De Vries said. "I consider myself a control pitcher. So to be successful, I have to have good fastball command and get my offspeed [pitches] in. If I'm doing that, I feel like I can go up against anyone. But if I'm not doing that, we'll find out."
Opposing the hometown favorite will be A's right-hander Jarrod Parker. The rookie will make his seventh start of the season after allowing two runs or fewer in all but one of his first six outings.
Parker showed off some of his best stuff in his most recent start against the Angels on May 23, touching 95 miles per hour multiple times. That velocity helped him strike out a career-high eight while only walking one man.
"I thought that was his best start of the year," Oakland manager Bob Melvin said. "His velocity climbed back up, he had good touch with all of his pitches. That's the guy we envisioned him being as far as stuff goes, and he had a confident look on his face."
A's: Coco trying to find stroke
Center fielder Coco Crisp is only 2-of-29 since being activated from the disabled list on May 21. He was 0-for-5 during Monday's game, grounding into two double plays.
"I feel good up there," Crisp said over the weekend. "It's definitely a grind mentally more so than physically. I just try to keep on going out there and give 100 percent and, hopefully, turn a corner. We're out here working -- we all are. We're doing a good job of pushing and grinding, before and during the games, which makes it that much harder when you're not succeeding."
Twins: Willingham hurts old team
Josh Willingham scored the go-ahead run on Monday in his first game against his former team, in which he went 1-for-3 with an RBI double. He hit .246 with a career-high 29 home runs and 98 RBIs for the A's last season.
Between De Vries and Parker, only Parker has previously faced one of the opposing teams' hitters. Minnesota's Jamey Carroll was 2-for-2 against Parker while playing with the Dodgers in 2011.