Additionally, Wilson will be facing Yu Darvish, the pitcher the Rangers essentially chose to spend their money on instead of him.
Wilson was a key member of the Rangers' American League championship teams the past two seasons, but signed with the Angels in the offseason.
The 31-year-old Wilson has pitched well as the Angels have struggled to a slow start this season, though they have now won seven of their past 10 games.
He is 4-2 with a 2.61 ERA and is coming off a strong performance in his last outing Friday, when he pitched eight innings and gave up six hits and two earned runs in a 6-2 victory over the Blue Jays.
Wilson says he is ready for a hostile reception in Arlington.
"I think the biggest thing will just be that we'll be playing in front of a huge crowd in a stadium that's relatively hostile to our team -- and I'm sure will be fairly hostile to me," he said. "I think a lot of people will boo me and stuff.
"The main objective is just focusing on the baseball aspect of it and preparing to get their guys out."
Wilson also knows he faces a big challenge against the Rangers' offense that often made life easier for him the past two seasons.
"Obviously when you change teams within the division, at some point you're going to play your old team and they've won the division the past two years because they're great hitters," he said. "I have a tall task.
"Some of those guys saw me pitch. Some of them caught me. So they have an idea of my stuff or whatever, what my approach is. I'm just going to have to try to stay one step ahead."
The 25-year-old Darvish has been terrific in his first season in the Major Leagues after a stellar career in Japan.
He is 4-1 with a 2.54 ERA in six starts and has struck out 44 in 39 innings.
He lost for the first time as a Ranger on Saturday, working six innings and allowing three earned runs and six hits while striking out 11 in a 4-2 loss at Cleveland.
The Rangers and Angels were expected to fight it out for the AL West championship this season, and this is their first meeting of the season.
Darvish is trying to take it as another step in his development as a Major League pitcher.
"The preparation is the same," he said. "I'm not going to change anything. I might change something once the game starts and I see how their hitters are doing.
"C.J. Wilson is a very good pitcher and Albert Pujols is a very good hitter. They have other good hitters and pitchers on their team. I'm happy to pitch against them and I'll do my best."
Angels: Iannetta to DL
Catcher Chris Iannetta will undergo surgery on his right wrist Friday that will keep him out of action an estimated 6-8 weeks, the Angels announced Thursday.
Iannetta initially sustained the injury when he was hit by a pitch on May 2, the same night he caught Jered Weaver's no-hitter.
The Angels had not announced a roster move as of Thursday night, but they will do so before Friday's game.
The Angels have been shut out seven times already this season, the most in the Major Leagues.
Rangers: Hamilton staying hot
Two days after Josh Hamilton became the 16th player to hit four home runs in a single game, he added to his season total with a two-run, first-inning shot in the second game of a doubleheader against Baltimore.
It was Hamilton's 15th on the season, and he finished Thursday with a .395 batting average.
Adrian Beltre has now been a part of a pair of four-homer games and has homered in each of those games. Beltre was a member of the Los Angeles Dodgers when Shawn Green went deep four times on May 23, 2002, at Milwaukee.
The only other player to participate in two games in which a teammate had a four-homer game was pitcher Gene Garber, who pitched in four-homer games for Philadelphia's Mike Schmidt in 1976 and Atlanta's Bob Horner in 1986.
Texas took the season series last year by winning 12 of the 19 games between the two squads. The Rangers won eight of their final 10 meetings against the Angels in 2011.
Texas has taken the last three season series between the two clubs.