The A's return home after a 5-4 East Coast trip, winning the final two games against the Rays at Tropicana Field.
Squaring off in the first game on Tuesday will be A's righty Jarrod Parker and Blue Jays lefty Ricky Romero.
Parker gets the call after manager Bob Melvin changed his mind about switching him and veteran Brandon McCarthy in the totation, taking advantage of Monday's off-day to give Parker extra rest.
Parker will be making his third start of the season. In his 13 innings pitched, he has allowed 11 hits and just two runs, striking out nine while walking three. Opponents are batting .234 against him.
Romero (4-0, 3.64) is coming off a victory last Wednesday against the Rangers, tossing eight innings and allowing five earned runs. The Blue Jays offense spotted him 11 runs.
Toronto shortstop Yunel Escobar, who sat out for the first time this season on Sunday, will be back in the lineup after the off-day Monday. Manager John Farrell felt Sunday was an appropriate time to give Escobar an extended period of rest.
"I think the need to give him a day off, in combination with [Monday], so he has two days down," Farrell said. "It became pretty apparent on the schedule, he has played every inning of the season so far and while he is swinging the bat better of late I still think the overriding thing was an additional day of rest."
Blue Jays: Johnson not sore
Second baseman Kelly Johnson was back in Toronto's lineup on Sunday, one day after being removed from Saturday night's game against the Angels because of soreness in his legs.
"He has a history of some dehydration [issues] that he has to maintain," Farrell said. "He was cramping up the day before, and because of those cramps on Friday night, he felt a little bit sore, and it was kind of hanging around late in the game. When he got through that last at-bat, we were going to get him off his feet."
Johnson legged out and infield single on Sunday, displaying no signs of injury.
Athletics: Preparing for Manny's return
Manager Bob Melvin expects the buzz in Oakland over Manny Ramirez's return to the Major Leagues to increase as the end of his 50-game suspension on May 30 draws closer.
Ramirez, currently in Phoenix working in extended spring training games, will go on a 10-game Minor League assignment before they call him up when the suspension ends.
"He knows where he is in his career," Melvin said. "And he knows the effect he can have on young guys."
Ramirez, a career .312 hitter with 555 home runs and 1,813 RBIs, batted .059 in five games with Tampa Bay last season
"DH has been his role and that's what we envision him doing," Melvin continued. "We'll have to see what we'll do, roster-wise."
The Athletics have committed 11 errors in their last 12 games after making eight over their first 16 contests.
The Blue Jays split four games in Oakland last season but lost the season series to the Athletics, 3-4.