Dating back to his first start of the season, Humber has retired 29 straight batters. Mark Buehrle's 45 consecutive outs is the White Sox record.
"I'm not sure what to say other than he can pitch and it comes down to command," pitching coach Don Cooper said. "He can do a lot things -- he can change speeds, he has curve, slider, changeup, [and] fastball. I think it stems from being aggressive and commanding fastball."
The Red Sox counter with a pitcher of their own coming off a more-than-effective start. Felix Doubront was left with a no-decision his last time on the mound, but that can be chalked up to a bullpen collapse. The lefty exited after six innings of four-hit, one-run ball with a 9-1 lead over the Yankees. But the bullpen troubles still couldn't take away Doubront's seven-strikeout performance.
"Those things happen. That's baseball," said Doubront after his last start. "I deserved better, but I'm with my team. For me, it was great, but I don't feel that good because we lost."
Despite Humber and Doubront coming off excellent outings, both will essentially be entering uncharted territories. Doubront has never faced any of the White Sox players and Humber has minimal experience against the Red Sox lineup, with Kevin Youkilis' seven at-bats the most of any Boston player.
White Sox: Konerko moving up in record books
Paul Konerko hit his 400th career home run on Wednesday, which moves him past Andres Galarraga and Al Kaline into 48th place on the all-time list. Konerko also moved past the 2,000 mark for career hits in a White Sox uniform. The veteran slugger's three hits Wednesday makes him the fifth Chicago player to reach the 2,000 milestone.
Red Sox: Ortiz off to a quick start
David Ortiz is batting an American League-leading .424 and has reached base safely in 16 of the season's first 17 games. His 28 hits in April is a career high.
White Sox manager Robin Ventura will face his former skipper when the Red Sox come into town. Boston manager Bobby Valentine led the Mets when Ventura was there from 1999 to 2001. Ventura won a National League Gold Glove Award in his final year under Valentine.