Between his time with the Nationals last season and his three starts with the A's this season, Milone's teams are 7-1 in his starting assignments.
He'll try and keep up such a pace on Tuesday, when the A's square off against the White Sox at the Coliseum.
Milone allowed seven hits in five innings against the Angels on Thursday, but managed to limit any major damage, allowing only two runs for the win.
"It feels great to come back home and pitch well," Milone, a Saugus, Calif., native said after his last start. "It's important to come back and, first game being able to pitch close to home, to do well and to get a win for the team and for the people that came out to support."
Milone will be up against White Sox right-hander Gavin Floyd, who is coming off a subpar start against the Orioles on Thursday.
Floyd surrendered five runs on six hits in six innings to take the loss, his second of the season.
A bright spot for Floyd so far this season has been his strikeout total, ringing up 16 in 17 2/3 innings. However, he's yet to go past the sixth inning in his three starts and is 12-11 lifetime in April with a 5.54 career ERA.
"Today was what it was," Floyd said after Thursday's game. "I don't even think about that stuff."
White Sox: Humber gets Player of the Week honors
After throwing the 21st perfect game in Major League history on Saturday, Philip Humber was named the American League Player of the Week on Monday.
Humber needed only 96 pitches to blank the Mariners, 4-0. He struck out nine batters and didn't allow a three-ball count until the ninth inning in the first complete game and the first shutout of his career.
A's: Crisp back in lineup
Having missed five consecutive games because of a head cold that led to an inner-ear problem, Coco Crisp returned to the lineup Monday for the A's.
"It's always nice to have Coco back in the lineup," manager Bob Melvin said. "Even when he's struggling, you feel like he's always going to get a hit. You know he's always prepared. Whenever he's out, you can feel it. It's good to have him back."
With Luke Hughes joining the A's and getting the start at third base for Monday's game against the White Sox, Josh Donaldson was demoted to Triple-A Sacramento.
"It wasn't for a lack of effort, and he really did handle himself beautifully defensively," Melvin said. "I know he would have liked to have swung the bat better, but at the big league level, to an extent, you have to produce. I don't feel great about the fact he's going down right now, but hopefully this isn't the last time we've seen him because he's a good athlete and has a lot of ability."
Oakland is 1-9 this season when trailing after seven innings.
The White Sox have gone 9-6 in their last 15 games in Oakland, compared to 6-28 in their previous 34.
Gavin Floyd is 3-1 with a 2.35 ERA in seven career starts against Oakland.