Proving to be one of the team's most significant additions, the right-hander has blanked opponents for 15 1/3 straight innings, in which he's given up just seven hits and struck out 10.
He'll try and keep that going on Monday against the White Sox at Oakland Coliseum in the opening game of a three-game series.
Colon's most impressive feat came in his last start on Wednesday against the Angels, where he tossed 38 consecutive strikes and got the win by giving up only four hits in eight innings.
"I think he could throw a strike with his eyes closed if he had to, the way he's been for us," said A's manager Bob Melvin.
Meanwhile, Jake Peavy will take the mound for the White Sox, trying to get his third win of the season.
Tossing seven solid innings against the Orioles on Wednesday, the right-hander gave up one run on four hits for his second straight win. In complete command of his pitches, Peavy struck out eight and walked none.
"I don't know what I can or can't be after what I've gone through, but I can promise you my effort and preparation is going to be there," Peavy said after his last start. "When you go out there healthy, you have a better chance of executing than when you're not and worrying about everything else but that. I feel very blessed to hopefully stay this way for the majority of this year and give my team a quality effort every fifth day."
White Sox: Lillibridge gets start in front of family, friends
White Sox utility player Brent Lillibridge received a rare start on Sunday, replacing regular left fielder Dayan Viciedo for the series finale in Seattle.
A Seattle-area native, Lillibridge sent out a mass text to family and friends once he saw his name in the lineup. He finished the day 2-for-4.
Paul Konerko is just two home runs shy of 400 for his career. Konerko hit one on Saturday in his first at-bat, and barely missed another home run in his second plate appearance, as the ball bounced off the top of the left-field wall.
A's: Hughes claimed from Twins
The A's claimed infielder Luke Hughes off waivers from Minnesota on Sunday, likely signaling a change at third base for the club.
With Hughes, a career .224 hitter, set to join the team Monday, it's probable that Oakland will demote Josh Donaldson, who is batting .094 through nine games.
"He's a versatile guy that can play anywhere in the infield," Melvin said. "He's got a little power, and we'll see what he has to offer."
Coco Crisp was held out of the A's lineup for a fifth consecutive day on Sunday, as he continues to recover from a head cold that resulted in an inner-ear infection.
"He's better today," Melvin said. "For all the guys who had the flu, he's had it a little more than that. If it was just the flu, I know Coco would have been out on the field. He's a tough guy. We were dealing with a little bit more. I think we're getting past that."
The A's are 2-9 this season when their opponent scores first.
The White Sox have allowed three runs or fewer in nine of 15 games this season.